An ex vivo study of foam cell formation and cholesterol clearance in macrophages isolated from patients with hypertriglyceridemia and low high-density lipoprotein cholesterol treated with high-dose simvastatin

Annabelle Rodriguez, Rita Fishelevich

Research output: Contribution to journalShort surveypeer-review

Abstract

High-density lipoproteins (HDL) are thought to be cardio-protective due to their role in decreasing cholesterol accumulation and in enhancing cholesterol removal from foam cells. Our study will examine foam cell formation and HDL-mediated cholesterol removal from macrophages isolated from patients with hypertriglyceridemia and low HDL. Peripheral blood monocytes and lipoproteins will be isolated from donors before and after 6-12 weeks on high-dose simvastatin (80 mg). The isolated lipoproteins from each donor will be incubated with their own macrophages for the study of foam cell formation and HDL-mediated cholesterol efflux. We expect to show that simvastatin increases HDL cholesterol, decreases triglyceride levels, and is associated with less foam cell formation and greater HDL-mediated cholesterol clearance.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalHeartDrug
Volume1
Issue number1
DOIs
StatePublished - Dec 1 2001

Keywords

  • Atherosclerosis
  • Cholesterol clearance
  • Foam cells
  • Macrophages
  • Simvastatin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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