An Evolutionary Heuristic Approach for Functional Modules Identification from Composite Biological Data

I. A. Maraziotis, A. Dragomir, A. Bezerianos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Modular structures are key features of the complex biological networks which control the functioning and dynamics of the living cell. In order to unravel this intricate modularity we propose an algorithm having evolutionary features that unveils and optimizes sub-networks within a weighted graph of protein interactions. The graph is enriched by integrating information from gene expression profiles. Functional modules are retrieved by expanding a kernel protein set that originates from 'seed' proteins and validated through biological and topological criteria. The modules obtained are further refined using a framework based on binary particle swarm optimization.

Original languageEnglish (US)
Title of host publicationIFMBE Proceedings
Pages673-677
Number of pages5
Volume23
DOIs
StatePublished - 2009
Externally publishedYes
Event13th International Conference on Biomedical Engineering, ICBME 2008 - , Singapore
Duration: Dec 3 2008Dec 6 2008

Other

Other13th International Conference on Biomedical Engineering, ICBME 2008
CountrySingapore
Period12/3/0812/6/08

Fingerprint

Proteins
Composite materials
Gene expression
Evolutionary algorithms
Particle swarm optimization (PSO)
Seed
Cells

Keywords

  • data integration
  • functional modules
  • particle swarm optimization
  • protein interaction network
  • protein-protein interaction

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Maraziotis, I. A., Dragomir, A., & Bezerianos, A. (2009). An Evolutionary Heuristic Approach for Functional Modules Identification from Composite Biological Data. In IFMBE Proceedings (Vol. 23, pp. 673-677) https://doi.org/10.1007/978-3-540-92841-6_165

An Evolutionary Heuristic Approach for Functional Modules Identification from Composite Biological Data. / Maraziotis, I. A.; Dragomir, A.; Bezerianos, A.

IFMBE Proceedings. Vol. 23 2009. p. 673-677.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Maraziotis, IA, Dragomir, A & Bezerianos, A 2009, An Evolutionary Heuristic Approach for Functional Modules Identification from Composite Biological Data. in IFMBE Proceedings. vol. 23, pp. 673-677, 13th International Conference on Biomedical Engineering, ICBME 2008, Singapore, 12/3/08. https://doi.org/10.1007/978-3-540-92841-6_165
Maraziotis, I. A. ; Dragomir, A. ; Bezerianos, A. / An Evolutionary Heuristic Approach for Functional Modules Identification from Composite Biological Data. IFMBE Proceedings. Vol. 23 2009. pp. 673-677
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