TY - JOUR
T1 - An evaluation of the variance components approach
T2 - Type I error, power and size of the estimated effect
AU - Shugart, Yin Yao
AU - O'Connell, Jeffrey R.
AU - Wilson, Alexander F.
PY - 2002
Y1 - 2002
N2 - In order to evaluate the statistical properties of the variance components method implemented in SOLAR and GENEHUNTER2, the type I error rate, power and estimated size of modelled effects were determined using computer simulation. Results suggested that the type I error rate was quite conservative when the variance was completely due to random effects. However, when either a polygenic effect or an unlinked single locus component effect was included in the generating models the type I error rate was closer to the nominal level. The size of the polygenic or single locus effect appeared to influence the type I error rate. Results suggested that the variance components method underestimated the variance attributed to a single locus effect and overestimated the variance attributed to a polygenic effect in the models considered regardless of the source of variation.
AB - In order to evaluate the statistical properties of the variance components method implemented in SOLAR and GENEHUNTER2, the type I error rate, power and estimated size of modelled effects were determined using computer simulation. Results suggested that the type I error rate was quite conservative when the variance was completely due to random effects. However, when either a polygenic effect or an unlinked single locus component effect was included in the generating models the type I error rate was closer to the nominal level. The size of the polygenic or single locus effect appeared to influence the type I error rate. Results suggested that the variance components method underestimated the variance attributed to a single locus effect and overestimated the variance attributed to a polygenic effect in the models considered regardless of the source of variation.
KW - Power
KW - Simulation
KW - Type I error
KW - Variance components approach
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U2 - 10.1038/sj/ejhg/5200772
DO - 10.1038/sj/ejhg/5200772
M3 - Article
C2 - 11938444
VL - 10
SP - 133
EP - 136
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 2
ER -