An evaluation of the structure of schizophrenia spectrum personality disorders

Gerald Nestadt, J. Hanfelt, K. Y. Liang, M. Lamacz, P. Wolyniec, Ann E Pulver

Research output: Contribution to journalArticle

Abstract

Research into the genetics of schizophrenia has revealed the importance of a spectrum of conditions that may indicate the underlying genetic diathesis for this condition. Important among these are specific personally disorders; schizotypal, paranoid, and schizoid. Despite specified criteria in the DSM-III-R, demonstration of their validity remains inconclusive and therefore a phenotype for use in genetic analyses is lacking. This article describes the internal structure of these personality disorders. Six hundred and twenty-one relatives of schizophrenic probands in multiple-affected families were examined using a modified SIDP. Latent class analytic techniques were employed to study the interrelationships of the individual DSM-III-R personality disorder criteria. The results reveal a unidimensional structure for DSM-III-R paranoid and schizoid personality disorders. The degree to which an individual belongs to each disorder is related to the number of criteria met. The DSM-III-R criteria defined for schizotypal personality disorder fall into three groups; these are paranoid, schizoid, and 'positive symptom' schizotypy. External validation of these classes will be valuable.

Original languageEnglish (US)
Pages (from-to)288-298
Number of pages11
JournalJournal of Personality Disorders
Volume8
Issue number4
StatePublished - 1994

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Personality Disorders
Diagnostic and Statistical Manual of Mental Disorders
Schizophrenia
Paranoid Personality Disorder
Schizoid Personality Disorder
Schizotypal Personality Disorder
Genetic Research
Disease Susceptibility
Phenotype

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

An evaluation of the structure of schizophrenia spectrum personality disorders. / Nestadt, Gerald; Hanfelt, J.; Liang, K. Y.; Lamacz, M.; Wolyniec, P.; Pulver, Ann E.

In: Journal of Personality Disorders, Vol. 8, No. 4, 1994, p. 288-298.

Research output: Contribution to journalArticle

Nestadt, Gerald ; Hanfelt, J. ; Liang, K. Y. ; Lamacz, M. ; Wolyniec, P. ; Pulver, Ann E. / An evaluation of the structure of schizophrenia spectrum personality disorders. In: Journal of Personality Disorders. 1994 ; Vol. 8, No. 4. pp. 288-298.
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