An Evaluation of Pulmonary Atelectasis and its Re-expansion: Hyperpolarized 3He MRI in the Yorkshire Pig

Margaret A. Ferrante, Ali Asiaii, Masaru Ishii, David A. Roberts, Johan M. Edvinsson, Aman Jalali, Zebulon Z. Spector, Fabian Meisel, Rahim R. Rizi

Research output: Contribution to journalArticle

Abstract

Rationale and Objectives. Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atelectasis, and the pig with re-expansion of atelectasis. We compare HP 3He MRI findings with depictions of atelectasis by proton MRI. Materials and Methods. During end-expiration in the anesthetized and paralyzed Yorkshire pig (n = 6), HP 3He gas produced by the optical pumping spin-exchange method, was delivered via an endotracheal tube. For two separate groups, atelectasis was either induced by Fogarty-catheter occlusion balloon inflation (n = 3), or lateral chest wall administration of sodium hydroxide (NaOH) (n = 3). MRI was performed at time zero, at 5, 9, 13, 15, and 19 minutes after atelectasis production, 30 minutes after balloon deflation, and 10 and 30 minutes after recruitment of atelectatic areas with increased tidal volumes and added positive end-expiratory pressure. High-resolution, cross-sectional MR images were procured, and comparison was made with the traditional proton MRI. Results. Atelectatic areas by HP 3He MRI were easily distinguishable in both subject groups, and correlated with those located by proton MR. HP 3He MR images showed absence of ventilation, whereas proton MR images depicted dense, white areas. Re-expansion of atelectasis was well delineated by HP 3He MRI. Conclusion. HP 3He MRI may overcome many of the shortcomings of other well-established radiographic methods. HP 3He MRI is a novel, informative method for describing atelectasis and its re-expansion.

Original languageEnglish (US)
Pages (from-to)1283-1290
Number of pages8
JournalAcademic Radiology
Volume10
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Pulmonary Atelectasis
Swine
Magnetic Resonance Imaging
Protons
Balloon Occlusion
Sodium Hydroxide
Positive-Pressure Respiration
Tidal Volume
Economic Inflation
Thoracic Wall
Ventilation
Catheters
Gases

Keywords

  • Atelectasis
  • Hyperpolarized helium
  • MRI
  • Pulmonary imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Ferrante, M. A., Asiaii, A., Ishii, M., Roberts, D. A., Edvinsson, J. M., Jalali, A., ... Rizi, R. R. (2003). An Evaluation of Pulmonary Atelectasis and its Re-expansion: Hyperpolarized 3He MRI in the Yorkshire Pig. Academic Radiology, 10(11), 1283-1290. https://doi.org/10.1016/S1076-6332(03)00469-0

An Evaluation of Pulmonary Atelectasis and its Re-expansion : Hyperpolarized 3He MRI in the Yorkshire Pig. / Ferrante, Margaret A.; Asiaii, Ali; Ishii, Masaru; Roberts, David A.; Edvinsson, Johan M.; Jalali, Aman; Spector, Zebulon Z.; Meisel, Fabian; Rizi, Rahim R.

In: Academic Radiology, Vol. 10, No. 11, 11.2003, p. 1283-1290.

Research output: Contribution to journalArticle

Ferrante, MA, Asiaii, A, Ishii, M, Roberts, DA, Edvinsson, JM, Jalali, A, Spector, ZZ, Meisel, F & Rizi, RR 2003, 'An Evaluation of Pulmonary Atelectasis and its Re-expansion: Hyperpolarized 3He MRI in the Yorkshire Pig', Academic Radiology, vol. 10, no. 11, pp. 1283-1290. https://doi.org/10.1016/S1076-6332(03)00469-0
Ferrante, Margaret A. ; Asiaii, Ali ; Ishii, Masaru ; Roberts, David A. ; Edvinsson, Johan M. ; Jalali, Aman ; Spector, Zebulon Z. ; Meisel, Fabian ; Rizi, Rahim R. / An Evaluation of Pulmonary Atelectasis and its Re-expansion : Hyperpolarized 3He MRI in the Yorkshire Pig. In: Academic Radiology. 2003 ; Vol. 10, No. 11. pp. 1283-1290.
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abstract = "Rationale and Objectives. Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atelectasis, and the pig with re-expansion of atelectasis. We compare HP 3He MRI findings with depictions of atelectasis by proton MRI. Materials and Methods. During end-expiration in the anesthetized and paralyzed Yorkshire pig (n = 6), HP 3He gas produced by the optical pumping spin-exchange method, was delivered via an endotracheal tube. For two separate groups, atelectasis was either induced by Fogarty-catheter occlusion balloon inflation (n = 3), or lateral chest wall administration of sodium hydroxide (NaOH) (n = 3). MRI was performed at time zero, at 5, 9, 13, 15, and 19 minutes after atelectasis production, 30 minutes after balloon deflation, and 10 and 30 minutes after recruitment of atelectatic areas with increased tidal volumes and added positive end-expiratory pressure. High-resolution, cross-sectional MR images were procured, and comparison was made with the traditional proton MRI. Results. Atelectatic areas by HP 3He MRI were easily distinguishable in both subject groups, and correlated with those located by proton MR. HP 3He MR images showed absence of ventilation, whereas proton MR images depicted dense, white areas. Re-expansion of atelectasis was well delineated by HP 3He MRI. Conclusion. HP 3He MRI may overcome many of the shortcomings of other well-established radiographic methods. HP 3He MRI is a novel, informative method for describing atelectasis and its re-expansion.",
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T1 - An Evaluation of Pulmonary Atelectasis and its Re-expansion

T2 - Hyperpolarized 3He MRI in the Yorkshire Pig

AU - Ferrante, Margaret A.

AU - Asiaii, Ali

AU - Ishii, Masaru

AU - Roberts, David A.

AU - Edvinsson, Johan M.

AU - Jalali, Aman

AU - Spector, Zebulon Z.

AU - Meisel, Fabian

AU - Rizi, Rahim R.

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N2 - Rationale and Objectives. Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atelectasis, and the pig with re-expansion of atelectasis. We compare HP 3He MRI findings with depictions of atelectasis by proton MRI. Materials and Methods. During end-expiration in the anesthetized and paralyzed Yorkshire pig (n = 6), HP 3He gas produced by the optical pumping spin-exchange method, was delivered via an endotracheal tube. For two separate groups, atelectasis was either induced by Fogarty-catheter occlusion balloon inflation (n = 3), or lateral chest wall administration of sodium hydroxide (NaOH) (n = 3). MRI was performed at time zero, at 5, 9, 13, 15, and 19 minutes after atelectasis production, 30 minutes after balloon deflation, and 10 and 30 minutes after recruitment of atelectatic areas with increased tidal volumes and added positive end-expiratory pressure. High-resolution, cross-sectional MR images were procured, and comparison was made with the traditional proton MRI. Results. Atelectatic areas by HP 3He MRI were easily distinguishable in both subject groups, and correlated with those located by proton MR. HP 3He MR images showed absence of ventilation, whereas proton MR images depicted dense, white areas. Re-expansion of atelectasis was well delineated by HP 3He MRI. Conclusion. HP 3He MRI may overcome many of the shortcomings of other well-established radiographic methods. HP 3He MRI is a novel, informative method for describing atelectasis and its re-expansion.

AB - Rationale and Objectives. Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atelectasis, and the pig with re-expansion of atelectasis. We compare HP 3He MRI findings with depictions of atelectasis by proton MRI. Materials and Methods. During end-expiration in the anesthetized and paralyzed Yorkshire pig (n = 6), HP 3He gas produced by the optical pumping spin-exchange method, was delivered via an endotracheal tube. For two separate groups, atelectasis was either induced by Fogarty-catheter occlusion balloon inflation (n = 3), or lateral chest wall administration of sodium hydroxide (NaOH) (n = 3). MRI was performed at time zero, at 5, 9, 13, 15, and 19 minutes after atelectasis production, 30 minutes after balloon deflation, and 10 and 30 minutes after recruitment of atelectatic areas with increased tidal volumes and added positive end-expiratory pressure. High-resolution, cross-sectional MR images were procured, and comparison was made with the traditional proton MRI. Results. Atelectatic areas by HP 3He MRI were easily distinguishable in both subject groups, and correlated with those located by proton MR. HP 3He MR images showed absence of ventilation, whereas proton MR images depicted dense, white areas. Re-expansion of atelectasis was well delineated by HP 3He MRI. Conclusion. HP 3He MRI may overcome many of the shortcomings of other well-established radiographic methods. HP 3He MRI is a novel, informative method for describing atelectasis and its re-expansion.

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