An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection

Jeffrey J. Sevigny, Steven M. Albert, Michael P. McDermott, Giovanni Schifitto, Justin Charles McArthur, Ned Sacktor, Katherine Conant, Ola A. Selnes, Yaakov Stern, Daniel R. McClernon, Donna Palumbo, Karl Kieburtz, Garrett Riggs, Bruce Cohen, Karen Marder, Leon G. Epstein

Research output: Contribution to journalArticle

Abstract

Background: Several markers of immuneactivation have been identified as potential prognostic markers for human immunodeficiency virus (HIV)-associated morbidity and mortality, but the results from studies are conflicting. Objective: To evaluate whether neurocognitive status and baseline levels of plasma and cerebrospinal fluid tumor necrosis factor α (TNF-α), macrophage chemoattractant protein 1 (MCP-1), matrix metalloproteinase 2 (MMP-2), or macrophage colony-stimulating factor (M-CSF) are associated with time to death in a cohort with advanced HIV infection. Design: Cohort study. Setting: Enrollees in the Northeast AIDS Dementia Study. Participants: Three hundred twenty-nine subjects who were positive for HIV-1 and had a CD4 cell count of less than 200/μL (or

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalArchives of Neurology
Volume64
Issue number1
DOIs
StatePublished - Jan 2007

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Virus Diseases
Biomarkers
HIV
Macrophage Colony-Stimulating Factor
Matrix Metalloproteinase 2
Chemotactic Factors
CD4 Lymphocyte Count
Cerebrospinal Fluid
Dementia
HIV-1
Acquired Immunodeficiency Syndrome
Cohort Studies
Tumor Necrosis Factor-alpha
Macrophages
Morbidity
Mortality
Proteins
Predictors
Activation
Evaluation

ASJC Scopus subject areas

  • Neuroscience(all)

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An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection. / Sevigny, Jeffrey J.; Albert, Steven M.; McDermott, Michael P.; Schifitto, Giovanni; McArthur, Justin Charles; Sacktor, Ned; Conant, Katherine; Selnes, Ola A.; Stern, Yaakov; McClernon, Daniel R.; Palumbo, Donna; Kieburtz, Karl; Riggs, Garrett; Cohen, Bruce; Marder, Karen; Epstein, Leon G.

In: Archives of Neurology, Vol. 64, No. 1, 01.2007, p. 97-102.

Research output: Contribution to journalArticle

Sevigny, JJ, Albert, SM, McDermott, MP, Schifitto, G, McArthur, JC, Sacktor, N, Conant, K, Selnes, OA, Stern, Y, McClernon, DR, Palumbo, D, Kieburtz, K, Riggs, G, Cohen, B, Marder, K & Epstein, LG 2007, 'An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection', Archives of Neurology, vol. 64, no. 1, pp. 97-102. https://doi.org/10.1001/archneur.64.1.97
Sevigny, Jeffrey J. ; Albert, Steven M. ; McDermott, Michael P. ; Schifitto, Giovanni ; McArthur, Justin Charles ; Sacktor, Ned ; Conant, Katherine ; Selnes, Ola A. ; Stern, Yaakov ; McClernon, Daniel R. ; Palumbo, Donna ; Kieburtz, Karl ; Riggs, Garrett ; Cohen, Bruce ; Marder, Karen ; Epstein, Leon G. / An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection. In: Archives of Neurology. 2007 ; Vol. 64, No. 1. pp. 97-102.
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