An evaluation of human protein-protein interaction data in the public domain

Suresh Mathivanan, Balamurugan Periaswamy, T. K B Gandhi, Kumaran Kandasamy, Shubha Suresh, Riaz Mohmood, Y. L. Ramachandra, Akhilesh Pandey

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Protein-protein interaction (PPI) databases have become a major resource for investigating biological networks and pathways in cells. A number of publicly available repositories for human PPIs are currently available. Each of these databases has their own unique features with a large variation in the type and depth of their annotations. Results: We analyzed the major publicly available primary databases that contain literature curated PPI information for human proteins. This included BIND, DIP, HPRD, IntAct, MINT, MIPS, PDZBase and Reactome databases. The number of binary non-redundant human PPIs ranged from 101 in PDZBase and 346 in MIPS to 11,367 in MINT and 36,617 in HPRD. The number of genes annotated with at least one interactor was 9,427 in HPRD, 4,975 in MINT, 4,614 in IntAct, 3,887 in BIND and

Original languageEnglish (US)
Article numberS19
JournalBMC Bioinformatics
Volume7
Issue numberSUPPL.5
DOIs
StatePublished - Dec 18 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Structural Biology
  • Applied Mathematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Artificial Intelligence
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Software

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