Abstract
1. 1. Adult male and female squirrel monkeys were tested for behavioral responses to 5 min. social separation (alone in test room) followed by 30-sec. exposure to 2 humans wearing a leather capture glove. 2. 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg. 3. 3. Measured behaviors were number and type of vocalization and locomotor activity (duration in sec) in each of the two testing conditions. 4. 4. A dose-response relationship for bark/yap vocalizations during the 30-sec trials was established, with 1.0 mg/kg being the most effective dose. 5. 5. Males and females differed in the number of barks/yaps produced during 30-sec. trials at every drug dose. 6. 6. The present testing paradigm provides the basis for efficiently determining the extent of gender differences in dose/response relationships for drugs of possible therapeutic value in the treatment of anxiety-related behavioral disorders.
Original language | English (US) |
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Pages (from-to) | 677-685 |
Number of pages | 9 |
Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
Volume | 19 |
Issue number | 4 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
Keywords
- alarm
- separation
- squirrel monkey
- vocalization
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology