An ethologically based, stimulus and gender-sensitive nonhuman primate model for anxiety

John D. Newman, Megan J. Farley

Research output: Contribution to journalArticle

Abstract

1. 1. Adult male and female squirrel monkeys were tested for behavioral responses to 5 min. social separation (alone in test room) followed by 30-sec. exposure to 2 humans wearing a leather capture glove. 2. 2. Trials were preceded by intramuscular injection of an anticholinergic drug, benactyzine hydrochloride, in doses of 0.0, 0.6, 1.0, 2.0, and 3.0 mg/kg. 3. 3. Measured behaviors were number and type of vocalization and locomotor activity (duration in sec) in each of the two testing conditions. 4. 4. A dose-response relationship for bark/yap vocalizations during the 30-sec trials was established, with 1.0 mg/kg being the most effective dose. 5. 5. Males and females differed in the number of barks/yaps produced during 30-sec. trials at every drug dose. 6. 6. The present testing paradigm provides the basis for efficiently determining the extent of gender differences in dose/response relationships for drugs of possible therapeutic value in the treatment of anxiety-related behavioral disorders.

Original languageEnglish (US)
Pages (from-to)677-685
Number of pages9
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume19
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • alarm
  • separation
  • squirrel monkey
  • vocalization

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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