TY - JOUR
T1 - An essential role for BLNK in human B cell development
AU - Minegishi, Yoshiyuki
AU - Rohrer, Jurg
AU - Coustan-Smith, Elaine
AU - Lederman, Howard M.
AU - Pappu, Rajita
AU - Campana, Dario
AU - Chan, Andrew C.
AU - Conley, Mary Ellen
PY - 1999/12/3
Y1 - 1999/12/3
N2 - The signal transduction events that control the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been well delineated. In evaluating patients with absent B cells, a male with a homozygous splice defect in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified. Although this patient had normal numbers of pro-B cells, he had no pre-B cells or mature B cells, indicating that BLNK plays a critical role in orchestrating the pro-B cell to pre-B cell transition. The immune system and overall growth and development were otherwise normal in this patient, suggesting that BLNK function is highly specific.
AB - The signal transduction events that control the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been well delineated. In evaluating patients with absent B cells, a male with a homozygous splice defect in the cytoplasmic adapter protein BLNK (B cell linker protein) was identified. Although this patient had normal numbers of pro-B cells, he had no pre-B cells or mature B cells, indicating that BLNK plays a critical role in orchestrating the pro-B cell to pre-B cell transition. The immune system and overall growth and development were otherwise normal in this patient, suggesting that BLNK function is highly specific.
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U2 - 10.1126/science.286.5446.1954
DO - 10.1126/science.286.5446.1954
M3 - Article
C2 - 10583958
AN - SCOPUS:0033521148
SN - 0036-8075
VL - 286
SP - 1954
EP - 1957
JO - Science
JF - Science
IS - 5446
ER -