An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary

Deyin Xing, Alexander A. Berrebi, Chengbao Liu, Abby Richmond, Russell S Vang, Brigitte Maria Ronnett

Research output: Contribution to journalArticle

Abstract

A 53-yr-old woman who presented with elevated renal indices was discovered to have a 4.5 cm right renal mass and an incidental 9.7 cm left ovarian mass on imaging studies. She underwent a partial nephrectomy and bilateral salpingo-oophorectomy, revealing a chromophobe renal cell carcinoma and an unusual ovarian neoplasm with epithelioid cells displaying prominent signet ring cell-like morphology. Immunohistochemical analysis of the ovarian neoplasm demonstrated that the tumor cells were diffusely immunoreactive for smooth muscle markers and negative for all tested cytokeratins and epithelial membrane antigen. On the basis of these results, the tumor was interpreted as an unusual epithelioid smooth muscle neoplasm with extensive signet ring cell-like features. Along with primary ovarian signet ring stromal tumors and sclerosing stromal tumors, this example adds epithelioid smooth muscle neoplasms with unusual cytologic alterations to the list of uncommon nonepithelial tumors that can simulate metastatic signet ring cell carcinoma (Krukenberg tumor) in the ovary.

Original languageEnglish (US)
Pages (from-to)464-469
Number of pages6
JournalInternational Journal of Gynecological Pathology
Volume38
Issue number5
DOIs
StatePublished - Sep 1 2019

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Muscle Neoplasms
Signet Ring Cell Carcinoma
Smooth Muscle
Ovary
Neoplasms
Ovarian Neoplasms
Krukenberg Tumor
Kidney
Epithelioid Cells
Mucin-1
Ovariectomy
Keratins
Nephrectomy
Renal Cell Carcinoma

Keywords

  • Epithelioid smooth muscle neoplasm
  • Ovary
  • Signet ring cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

An Epithelioid Smooth Muscle Neoplasm Mimicking a Signet Ring Cell Carcinoma in the Ovary. / Xing, Deyin; Berrebi, Alexander A.; Liu, Chengbao; Richmond, Abby; Vang, Russell S; Ronnett, Brigitte Maria.

In: International Journal of Gynecological Pathology, Vol. 38, No. 5, 01.09.2019, p. 464-469.

Research output: Contribution to journalArticle

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