TY - JOUR
T1 - An Epidemic of Dyssynchrony. But What Does It Mean?
AU - Kass, David A.
N1 - Funding Information:
Supported by National Health Service (National Heart, Lung, and Blood Institute) grant PO1-HL077180 and the Abraham and Virginia Weiss Professorship. Dr. Kass is a consultant for Boston Scientific (Natick, Massachusetts), a company involved with cardiac resynchronization devices. The content of this Viewpoint in no way presents any intellectual or commercial conflict, because it deals with a question of pathophysiology and its detection by imaging modalities.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Cardiac resynchronization therapy (CRT) is used to treat a subset of heart failure patients with discoordinate wall motion. Defining appropriate patients is important, and, although electrical delay (wide QRS) is commonly used, recent data show that measures of mechanical dyssynchrony improve the sensitivity and specificity of predicting responders (including patients with narrow QRS complexes). This has stimulated studies of dyssynchrony per se, and the phenomenon now appears to be very common in virtually all forms of heart failure. However, what all this dyssynchrony means clinically, and how or whether it should be treated by CRT or other means, remains unclear.
AB - Cardiac resynchronization therapy (CRT) is used to treat a subset of heart failure patients with discoordinate wall motion. Defining appropriate patients is important, and, although electrical delay (wide QRS) is commonly used, recent data show that measures of mechanical dyssynchrony improve the sensitivity and specificity of predicting responders (including patients with narrow QRS complexes). This has stimulated studies of dyssynchrony per se, and the phenomenon now appears to be very common in virtually all forms of heart failure. However, what all this dyssynchrony means clinically, and how or whether it should be treated by CRT or other means, remains unclear.
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U2 - 10.1016/j.jacc.2007.09.027
DO - 10.1016/j.jacc.2007.09.027
M3 - Review article
C2 - 18174030
AN - SCOPUS:37449010748
SN - 0735-1097
VL - 51
SP - 12
EP - 17
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 1
ER -