An electron microscopic study of calcificaton of retinoblastoma

C. Chia Lee Lin; M. O.M. Tso

doi:10.1016/s0002-9394(14)71922-1

An electron microscopic study of calcificaton of retinoblastoma

C. Chia Lee Lin, M. O.M. Tso

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We examined three eyes with retinoblastoma that had clinical evidence of calcification. The light and electron microscopic study of the retinoblastoma cells from these eyes disclosed an intramitochondrial calcium deposition after plasmalemma disruption. Morphologically, calcium deposits initially occur as needle-like structures gathered within the mitochondrial membrane. With progressive necrotic liquefaction of tumor cells, microbodies develop a central calcified cone surrounded by an electron-translucent zone with coarse needle-like calcium deposition on the surface.

Original language	English (US)
Pages (from-to)	765-774
Number of pages	10
Journal	American journal of ophthalmology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/s0002-9394(14)71922-1
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/s0002-9394(14)71922-1

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title = "An electron microscopic study of calcificaton of retinoblastoma",

abstract = "We examined three eyes with retinoblastoma that had clinical evidence of calcification. The light and electron microscopic study of the retinoblastoma cells from these eyes disclosed an intramitochondrial calcium deposition after plasmalemma disruption. Morphologically, calcium deposits initially occur as needle-like structures gathered within the mitochondrial membrane. With progressive necrotic liquefaction of tumor cells, microbodies develop a central calcified cone surrounded by an electron-translucent zone with coarse needle-like calcium deposition on the surface.",

author = "{Chia Lee Lin}, C. and Tso, {M. O.M.}",

note = "Funding Information: From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois Eye and Ear Infirmary. This work was supported in part by Public Health Service Grant EYO1903 and Core Grant IP30 EY01792.",

year = "1983",

doi = "10.1016/s0002-9394(14)71922-1",

language = "English (US)",

volume = "96",

pages = "765--774",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "6",

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T1 - An electron microscopic study of calcificaton of retinoblastoma

AU - Chia Lee Lin, C.

AU - Tso, M. O.M.

N1 - Funding Information: From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois Eye and Ear Infirmary. This work was supported in part by Public Health Service Grant EYO1903 and Core Grant IP30 EY01792.

PY - 1983

Y1 - 1983

N2 - We examined three eyes with retinoblastoma that had clinical evidence of calcification. The light and electron microscopic study of the retinoblastoma cells from these eyes disclosed an intramitochondrial calcium deposition after plasmalemma disruption. Morphologically, calcium deposits initially occur as needle-like structures gathered within the mitochondrial membrane. With progressive necrotic liquefaction of tumor cells, microbodies develop a central calcified cone surrounded by an electron-translucent zone with coarse needle-like calcium deposition on the surface.

AB - We examined three eyes with retinoblastoma that had clinical evidence of calcification. The light and electron microscopic study of the retinoblastoma cells from these eyes disclosed an intramitochondrial calcium deposition after plasmalemma disruption. Morphologically, calcium deposits initially occur as needle-like structures gathered within the mitochondrial membrane. With progressive necrotic liquefaction of tumor cells, microbodies develop a central calcified cone surrounded by an electron-translucent zone with coarse needle-like calcium deposition on the surface.

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EP - 774

JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 6

ER -

An electron microscopic study of calcificaton of retinoblastoma

Abstract

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