An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system

P. R. Lowenstein, P. A. Slesinger, H. S. Singer, L. C. Walker, M. F. Casanova, D. L. Price, J. T. Coyle

Research output: Contribution to journalArticle

Abstract

The developmental distribution of the sodium-dependent high affinity choline uptake (SDHACU) system has been studied in the caudate and putamen of the baboon and of the human by in vitro autoradiography with the ligand, [3H]hemicholinium-3 ([3H]HCh3). Our results show that [3H]HCh3 binding sites in the newborn baboon and fetal human neostriatum are localized to patches, and then adopt a 'striosome-like' distribution in the juvenile baboon brain. These findings indicate a reorganization of [3H]HCh3 binding site distribution during the ontogeny of the primate neostriatum.

Original languageEnglish (US)
Pages (from-to)291-297
Number of pages7
JournalDevelopmental Brain Research
Volume34
Issue number2
DOIs
StatePublished - Aug 1987

Keywords

  • Baboon striatum
  • Basal ganglion
  • Choline uptake system
  • Development
  • [H]Hemicholinium binding

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Fingerprint Dive into the research topics of 'An autoradiographic study of the development of [<sup>3</sup>H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system'. Together they form a unique fingerprint.

  • Cite this