TY - JOUR
T1 - An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility
AU - Cingolani, Horacio E.
AU - Pérez, Néstor G.
AU - Camilión De Hurtado, María C.
PY - 2001/4
Y1 - 2001/4
N2 - An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.
AB - An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.
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U2 - 10.1152/physiologyonline.2001.16.2.88
DO - 10.1152/physiologyonline.2001.16.2.88
M3 - Article
C2 - 11390956
AN - SCOPUS:0035319914
SN - 0886-1714
VL - 16
SP - 88
EP - 91
JO - News in Physiological Sciences
JF - News in Physiological Sciences
IS - 2
ER -