An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility

Horacio E. Cingolani, Néstor G. Pérez, María C. Camilión De Hurtado

Research output: Contribution to journalArticle

Abstract

An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalNews in Physiological Sciences
Volume16
Issue number2
StatePublished - Apr 2001
Externally publishedYes

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Sodium-Hydrogen Antiporter
Endothelins
Angiotensin II
Myocardium

ASJC Scopus subject areas

  • Physiology

Cite this

Cingolani, H. E., Pérez, N. G., & Camilión De Hurtado, M. C. (2001). An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility. News in Physiological Sciences, 16(2), 88-91.

An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility. / Cingolani, Horacio E.; Pérez, Néstor G.; Camilión De Hurtado, María C.

In: News in Physiological Sciences, Vol. 16, No. 2, 04.2001, p. 88-91.

Research output: Contribution to journalArticle

Cingolani, HE, Pérez, NG & Camilión De Hurtado, MC 2001, 'An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility', News in Physiological Sciences, vol. 16, no. 2, pp. 88-91.
Cingolani, Horacio E. ; Pérez, Néstor G. ; Camilión De Hurtado, María C. / An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility. In: News in Physiological Sciences. 2001 ; Vol. 16, No. 2. pp. 88-91.
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