An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility

Horacio E. Cingolani, Néstor G. Pérez, María C. Camilión De Hurtado

Research output: Contribution to journalArticlepeer-review

Abstract

An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na+/H+ exchanger, increase in intracellular Na+, and the increase in the Ca2+ transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalNews in Physiological Sciences
Volume16
Issue number2
DOIs
StatePublished - Apr 2001

ASJC Scopus subject areas

  • Physiology

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