An atypical case of fatal zygomycosis: Simultaneous cutaneous and laryngeal infection in a patient with a non-neutropenic solid prostatic tumor

Kristine E. Johnson, Kevin Leahy, Christopher Owens, Joel N. Blankson, William G. Merz, Bradley J. Goldstein

Research output: Contribution to journalArticlepeer-review

Abstract

We describe what we believe is the first reported case of simultaneous highly invasive cutaneous and laryngopharyngeal zygomycosis in a non-neutropenic, nondiabetic but immunosuppressed patient with prostate cancer. An invasive fungal process was not suspected until late in the patient's hospital course; when it was, a tracheotomy and direct laryngoscopic biopsies were performed. Unresectable invasive zygomycosis with Rhizopus rhizopodiformis was diagnosed. The patient was managed with liposomal amphotericin B initially and later with palliative medical therapy until he died. This case emphasizes the need for a rapid and specific diagnosis with timely introduction of appropriate antifungal management, particularly now that voriconazole is frequently used as empiric prophy-laxis against aspergillosis in high-risk patients.

Original languageEnglish (US)
JournalEar, Nose and Throat Journal
Volume87
Issue number3
DOIs
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Otorhinolaryngology

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