An association between reduced interhemispheric EEG coherence in the temporal lobe and genetic risk for schizophrenia

Georg Winterer, Michael F. Egan, Thomas Rädler, Thomas Hyde, Richard Coppola, Daniel R. Weinberger

Research output: Contribution to journalArticle


Previous studies have suggested that schizophrenic patients show resting EEG replicate the results on the second data set. Power spectrum analysis suggested that schizophrenics are cortically hypoactivated, whereas in unaffected siblings, a tendency for hyperactivation was found. In contrast, spectral coherences (0.5-5 Hz) were reduced in both data sets in the temporal lobe areas in schizophrenics and in their unaffected siblings. Changes were most pronounced for the interhemispheric coherence linking both posterior temporal lobe areas. Relative risk calculations (λS) ranged between 3.7 and 9.8, depending on phenotype definition. Thus, while power spectrum EEG abnormalities may be state-dependent, reduced coherence as a possible measure of neuronal synchronization is familial and potentially a heritable trait related to genetic risk for schizophrenia.

Original languageEnglish (US)
Pages (from-to)129-143
Number of pages15
JournalSchizophrenia Research
Issue number1-2
StatePublished - Apr 15 2001
Externally publishedYes



  • Coherence
  • EEG
  • Relative risk
  • Schizophrenia
  • Sib-pair analysis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this