An assessment of the effects of internal neurolysis on a chronically compressed rat sciatic nerve

S. E. Mackinnon, J. P. O’Brien, A. L. Dellon, A. R. McLean, A. R. Hudson, D. A. Hunter

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Chronically compressed nerves were treated with three surgical modalities. Simple decompression was compared to internal neurolysis with and without the addition of extrafascicular steroid. Electrophysiologic, histologic, and morphometric assessments were performed. Compressed control nerves demonstrated changes compatible with severe nerve compression (Wallerian degeneration). With simple decompression, improvement in histologic and electrophysiologic parameters occurred. When internal neurolysis was added to the decompression, further improvement in histologic and electrophysiologic parameters was noted. There was no added improvement with the addition of steroids.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalPlastic and reconstructive surgery
Volume81
Issue number2
DOIs
StatePublished - Feb 1988
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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