An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia

D. S. Race; K. Tsapkini; J. Crinion; M. Newhart; C. Davis; Y. Gomez; A. E. Hillis; A. V. Faria

doi:10.1016/j.bandl.2013.09.004

An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia

D. S. Race, K. Tsapkini, J. Crinion, M. Newhart, C. Davis, Y. Gomez, A. E. Hillis, A. V. Faria

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the relationship between deficits in naming and areas of focal atrophy in primary progressive aphasia (a neurodegenerative disease that specifically affects language processing). We tested patients, across multiple input modalities, on traditional naming tasks (picture naming) and more complex tasks (sentence completion with a name, naming in response to a question) and obtained high resolution MRI. Across most tasks, error rates were correlated with atrophy in the left middle and posterior inferior temporal gyrus. Overall, this result converges with prior literature suggesting that this region plays a major role in modality independent lexical processing.

Original language	English (US)
Pages (from-to)	167-176
Number of pages	10
Journal	Brain and Language
Volume	127
Issue number	2
DOIs	https://doi.org/10.1016/j.bandl.2013.09.004
State	Published - Nov 2013

Keywords

Inferior temporal cortex
Lexical access
MRI
Naming
Neurodegeneration
Primary progressive aphasia

ASJC Scopus subject areas

Language and Linguistics
Experimental and Cognitive Psychology
Linguistics and Language
Cognitive Neuroscience
Speech and Hearing

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10.1016/j.bandl.2013.09.004

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title = "An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia",

abstract = "We investigated the relationship between deficits in naming and areas of focal atrophy in primary progressive aphasia (a neurodegenerative disease that specifically affects language processing). We tested patients, across multiple input modalities, on traditional naming tasks (picture naming) and more complex tasks (sentence completion with a name, naming in response to a question) and obtained high resolution MRI. Across most tasks, error rates were correlated with atrophy in the left middle and posterior inferior temporal gyrus. Overall, this result converges with prior literature suggesting that this region plays a major role in modality independent lexical processing.",

keywords = "Inferior temporal cortex, Lexical access, MRI, Naming, Neurodegeneration, Primary progressive aphasia",

author = "Race, {D. S.} and K. Tsapkini and J. Crinion and M. Newhart and C. Davis and Y. Gomez and Hillis, {A. E.} and Faria, {A. V.}",

note = "Funding Information: This publication was made possible by AHA grant 12SDG12080169 (AVF), and by NIH grants UL1 RR025005 from NCRR and NIH Roadmap for Medical Research (AVF); R01 DC011317 and R01 DC 03681 NIDCD (AH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of any of these Institutes. We gratefully acknowledge this support, and the participation of the participants. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "2013",

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doi = "10.1016/j.bandl.2013.09.004",

language = "English (US)",

volume = "127",

pages = "167--176",

journal = "Brain and Language",

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T2 - Evidence from primary progressive aphasia

AU - Race, D. S.

AU - Tsapkini, K.

AU - Crinion, J.

AU - Newhart, M.

AU - Davis, C.

AU - Gomez, Y.

AU - Hillis, A. E.

AU - Faria, A. V.

N1 - Funding Information: This publication was made possible by AHA grant 12SDG12080169 (AVF), and by NIH grants UL1 RR025005 from NCRR and NIH Roadmap for Medical Research (AVF); R01 DC011317 and R01 DC 03681 NIDCD (AH). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of any of these Institutes. We gratefully acknowledge this support, and the participation of the participants. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2013/11

Y1 - 2013/11

N2 - We investigated the relationship between deficits in naming and areas of focal atrophy in primary progressive aphasia (a neurodegenerative disease that specifically affects language processing). We tested patients, across multiple input modalities, on traditional naming tasks (picture naming) and more complex tasks (sentence completion with a name, naming in response to a question) and obtained high resolution MRI. Across most tasks, error rates were correlated with atrophy in the left middle and posterior inferior temporal gyrus. Overall, this result converges with prior literature suggesting that this region plays a major role in modality independent lexical processing.

AB - We investigated the relationship between deficits in naming and areas of focal atrophy in primary progressive aphasia (a neurodegenerative disease that specifically affects language processing). We tested patients, across multiple input modalities, on traditional naming tasks (picture naming) and more complex tasks (sentence completion with a name, naming in response to a question) and obtained high resolution MRI. Across most tasks, error rates were correlated with atrophy in the left middle and posterior inferior temporal gyrus. Overall, this result converges with prior literature suggesting that this region plays a major role in modality independent lexical processing.

KW - Inferior temporal cortex

KW - Lexical access

KW - MRI

KW - Naming

KW - Neurodegeneration

KW - Primary progressive aphasia

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An area essential for linking word meanings to word forms: Evidence from primary progressive aphasia

Abstract

Keywords

ASJC Scopus subject areas

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