An aptamer-based approach to continuous, real-time molecular measurements in vivo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real-time would advance our understanding of health and our ability to detect and treat disease. It would, for example, enable therapies guided by patientspecific pharmacokinetics, opening new dimensions in personalized medicine. In response, we have demonstrated the ability of electrochemical aptamer-based (E-AB) sensors to support continuous, multi-hour measurements directly in living subjects. Specifically, we have used E-AB sensors to perform real-time measurements of drugs in the bloodstream of live rats, achieving precise molecular measurements, relevant detection limits and high (3 s) temporal resolution, attributes suggesting the approach could prove an important window into the study of physiology and pharmacology.

Original languageEnglish (US)
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages1224-1225
Number of pages2
ISBN (Electronic)9780979806490
StatePublished - Jan 1 2016
Externally publishedYes
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

Keywords

  • Aptamer
  • Biosensor
  • Electrochemical
  • In vivo
  • Pharmacokinetics

ASJC Scopus subject areas

  • Control and Systems Engineering

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