Abstract
The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real-time would advance our understanding of health and our ability to detect and treat disease. It would, for example, enable therapies guided by patientspecific pharmacokinetics, opening new dimensions in personalized medicine. In response, we have demonstrated the ability of electrochemical aptamer-based (E-AB) sensors to support continuous, multi-hour measurements directly in living subjects. Specifically, we have used E-AB sensors to perform real-time measurements of drugs in the bloodstream of live rats, achieving precise molecular measurements, relevant detection limits and high (3 s) temporal resolution, attributes suggesting the approach could prove an important window into the study of physiology and pharmacology.
Original language | English (US) |
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Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
Publisher | Chemical and Biological Microsystems Society |
Pages | 1224-1225 |
Number of pages | 2 |
ISBN (Electronic) | 9780979806490 |
State | Published - Jan 1 2016 |
Externally published | Yes |
Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: Oct 9 2016 → Oct 13 2016 |
Other
Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
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Country/Territory | Ireland |
City | Dublin |
Period | 10/9/16 → 10/13/16 |
Keywords
- Aptamer
- Biosensor
- Electrochemical
- In vivo
- Pharmacokinetics
ASJC Scopus subject areas
- Control and Systems Engineering