TY - JOUR
T1 - An Apparent Cluster of Aplastic Anemia in a Small Population of Teenagers
AU - Linet, Martha S.
AU - Tielsch, James M.
AU - Markowitz, Jan A.
AU - Sensenbrenner, Lyle L.
AU - Mccaffrey, Lee D.
AU - Warm, Steven G.
AU - Vanderslice, Sandra F.
AU - Morgan, W. Fred
AU - Bearden, James D.
AU - Szklo, Moyses
PY - 1985/4
Y1 - 1985/4
N2 - Four teenagers with severe aplastic anemia, initially diagnosed and evaluated over a seven-year period at The Johns Hopkins Bone Marrow Transplant Unit, Baltimore, were residents of the same small town in South Carolina. Estimated annual incidence for that age group in the town, based on the four cases, was 100 times the expected rate. All four of the teenagers had attended one of two junior high schools. An exploratory survey of all high-school students, comparing risk factors of those who had attended the “affected” junior high school with those who had attended the “unaffected” junior high school, showed no associations with exposure to glue, paint or varnishes, pesticides, history of hepatitis or infectious mononucleosis, or use of chloramphenicol or other suspected drugs. Weak associations were found between the affected junior high school and employment in the textile industry and in agriculture (specifically peach orchards).
AB - Four teenagers with severe aplastic anemia, initially diagnosed and evaluated over a seven-year period at The Johns Hopkins Bone Marrow Transplant Unit, Baltimore, were residents of the same small town in South Carolina. Estimated annual incidence for that age group in the town, based on the four cases, was 100 times the expected rate. All four of the teenagers had attended one of two junior high schools. An exploratory survey of all high-school students, comparing risk factors of those who had attended the “affected” junior high school with those who had attended the “unaffected” junior high school, showed no associations with exposure to glue, paint or varnishes, pesticides, history of hepatitis or infectious mononucleosis, or use of chloramphenicol or other suspected drugs. Weak associations were found between the affected junior high school and employment in the textile industry and in agriculture (specifically peach orchards).
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U2 - 10.1001/archinte.1985.00360040053012
DO - 10.1001/archinte.1985.00360040053012
M3 - Article
C2 - 3985725
AN - SCOPUS:84941818192
VL - 145
SP - 635
EP - 640
JO - Archives of internal medicine (Chicago, Ill. : 1908)
JF - Archives of internal medicine (Chicago, Ill. : 1908)
SN - 2168-6106
IS - 4
ER -