An animal study of different treatments to prevent postoperative pelvic adhesions

Robert A. Graebe, Terri Lynn Cornelison, Sie‐Bin ‐B Pan, Florence P. Haseltine, Alan H. De Cherney, Gabriel Oelsner

Research output: Contribution to journalArticle

Abstract

A study was designed to test various high‐molecular‐weight solutions in the prevention of postoperative intraabdominal adhesions. The bicornuate rat uterus was used as the surgical model, and 80 mature white female rats underwent surgical injury of the right uterine horn. The rats were randomly divided into 5 groups: groups A, B, and C received 5 ml intraperitoneally of chondroitin sulfate, sodium carboxymethylcellulose, and 32% dextran 70, respectively; group D was treated with microsurgical repair; and group E, the control, received no therapy. The animals were killed postoperatively, and the adhesions were scored. Significantly better results in adhesion prevention were demonstrated in the sodium carboxymethylcellulose group vs. the other groups, except in group A where the difference was not significant.

Original languageEnglish (US)
Pages (from-to)53-55
Number of pages3
JournalMicrosurgery
Volume10
Issue number1
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Surgery

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    Graebe, R. A., Cornelison, T. L., Pan, SB. B., Haseltine, F. P., De Cherney, A. H., & Oelsner, G. (1989). An animal study of different treatments to prevent postoperative pelvic adhesions. Microsurgery, 10(1), 53-55. https://doi.org/10.1002/micr.1920100110