An analysis of tumor necrosis for α gene polymorphisms and haplotypes with natural clearance of hapatitis C virus infection

Chloe L Thio, J. J. Goedert, T. Mosbruger, D. Vlahov, S. A. Strathdee, S. J. O'Brien, J. Astemborski, David L Thomas

Research output: Contribution to journalArticle

Abstract

The cytokine tumor necrosis factor alpha (TNF-α) is important in generating an immune response against a hepatitis C virus (HCV) infection. The functions of TNF-α may be altered by single-nucleotide polymorphisms (SNPs) in its gene, TNF. We hypothesized that SNPs in TNF may be important in determining the outcome of an HCV infection. To test this hypothesis, we typed nine TNF SNPs in a cohort of individuals with well-defined HCV outcomes. Three of these SNPs were typed in a second cohort. Data were analyzed using logistic regression stratifying by ethnicity, since rates of HCV clearance differ in black subjects versus white subjects. The SNP -863A was associated with viral clearance in black subjects (odds ratios (OR) 0.52, 95% confidence interval (CI) 0.29-0.93). Furthermore, the common wild-type haplotype -863C/-308G was associated with viral persistence in black subjects (OR 1.91, 95% CI 1.24-2.95). These findings were independent of linkage with human leukocyte antigen (HLA) alleles. Further study of this polymorphism and haplotype is needed to understand these associations and the role of TNF-α in determining outcomes of HCV infection.

Original languageEnglish (US)
Pages (from-to)294-300
Number of pages7
JournalGenes and Immunity
Volume5
Issue number4
DOIs
StatePublished - Jun 2004

Fingerprint

Virus Diseases
Hepacivirus
Haplotypes
Single Nucleotide Polymorphism
Necrosis
Tumor Necrosis Factor-alpha
Genes
Neoplasms
Odds Ratio
Confidence Intervals
HLA Antigens
Logistic Models
Alleles
Cytokines

Keywords

  • Genetic epidemiology
  • Genetics
  • Infectious diseases
  • TNF
  • Viral hepatitis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

An analysis of tumor necrosis for α gene polymorphisms and haplotypes with natural clearance of hapatitis C virus infection. / Thio, Chloe L; Goedert, J. J.; Mosbruger, T.; Vlahov, D.; Strathdee, S. A.; O'Brien, S. J.; Astemborski, J.; Thomas, David L.

In: Genes and Immunity, Vol. 5, No. 4, 06.2004, p. 294-300.

Research output: Contribution to journalArticle

Thio, Chloe L ; Goedert, J. J. ; Mosbruger, T. ; Vlahov, D. ; Strathdee, S. A. ; O'Brien, S. J. ; Astemborski, J. ; Thomas, David L. / An analysis of tumor necrosis for α gene polymorphisms and haplotypes with natural clearance of hapatitis C virus infection. In: Genes and Immunity. 2004 ; Vol. 5, No. 4. pp. 294-300.
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