An analysis of T lymphocyte subpopulations in patients with Alzheimer's disease

M. S. Leffell, L. Lumsden, W. A. Steiger

Research output: Contribution to journalArticle

Abstract

The relative proportions of regulatory T lymphocyte subpopulations and T-lymphocyte proliferative responses to the mitogen phytohemagglutinin (PHA) were studied in 30 patients with clinically apparent Alzheimer's disease (mean age = 71.5). Comparisons were made with 30 age-matched, nondemented healthy controls (mean age = 68.8) and with 20 younger, normal adult controls (mean age = 27.5). The relative percentages of total peripheral T lymphocytes, T helper/inducer lymphocytes (Th), and T suppressor/cytotoxic lymphocytes (Ts) were similar between the Alzheimer patient group and the age-matched controls. However, when the two older groups were compared with the young adult controls, a significant decrease was seen in the percentage of Ts cells, with a concomitant increase in the ratio of Th:Ts. Lymphocyte proliferative responses to PHA were similar in the Alzheimer patients and their age-matched controls; however, when compared with the young adult controls, a significant decrease in responsiveness for both older groups was observed. These results confirm decreases in certain immune indices with aging, but suggest that there are no changes in T lymphocyte subsets or in lymphocyte proliferation, which are unique to Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalJournal of the American Geriatrics Society
Volume33
Issue number1
StatePublished - 1985
Externally publishedYes

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Lymphocyte Subsets
Young Adult
Alzheimer Disease
Phytohemagglutinins
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Lymphocytes
T-Lymphocyte Subsets
Cytotoxic T-Lymphocytes
Regulatory T-Lymphocytes
Mitogens
Research Design
Age Groups

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

An analysis of T lymphocyte subpopulations in patients with Alzheimer's disease. / Leffell, M. S.; Lumsden, L.; Steiger, W. A.

In: Journal of the American Geriatrics Society, Vol. 33, No. 1, 1985, p. 4-8.

Research output: Contribution to journalArticle

Leffell, M. S. ; Lumsden, L. ; Steiger, W. A. / An analysis of T lymphocyte subpopulations in patients with Alzheimer's disease. In: Journal of the American Geriatrics Society. 1985 ; Vol. 33, No. 1. pp. 4-8.
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