An Analysis of T Lymphocyte Subpopulations in Patients with Alzheimer's Disease

Mary S. Leffell, William A. Steiger

Research output: Contribution to journalArticle

Abstract

The relative proportions of regulatory T lymphocyte subpopulations and T lymphocyte proliferative responses to the mitogen phytohemagglutinin (PHA) were studied in 30 patients with clinically apparent Alzheimer's disease (mean age = 71.5). Comparisons were made with 30 age‐matched, nondemented healthy controls (mean age = 68.8) and with 20 younger, normal adult controls (mean age = 27.5). The relative percentages of total peripheral T lymphocytes, T helper/inducer lymphocytes (Th), and T suppressor/cytotoxic lymphocytes (Ts) were similar between the Alzheimer patient group and the age‐matched controls. However, when the two older groups were compared with the young adult controls, a significant decrease was seen in the percentage of Ts cells, with a concomitant increase in the ratio of Th:Ts. Lymphocyte proliferative responses to PHA were similar in the Alzheimer patients and their age‐matched controls; however, when compared with the young adult controls, a significant decrease in responsiveness for both older groups was observed. These results confirm decreases in certain immune indices with aging, but suggest that there are no changes in T lymphocyte subsets or in lymphocyte proliferation, which are unique to Alzheimer's disease. J Am Geriatr Soc 33:4, 1985 1985 The American Geriatrics Society

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalJournal of the American Geriatrics Society
Volume33
Issue number1
DOIs
StatePublished - Jan 1985

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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