An analysis of risk factors for human immunodeficiency virus infection among Chinese blood donors

Jingxing Wang, Jing Liu, Yi Huang, Tonghan Yang, Fuzhu Yao, Xiangdong Dong, Guoxin Wen, Xinhong Bi, Mingjiang Zhao, Xiuqiong Wen, Mei Huang, Yunlai Lü, Hongli Ma, Qilu Yu, David Wright, Nan Guo, Paul Ness, Hua Shan

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Information regarding the risk factors for human immunodeficiency virus (HIV) infection among Chinese donors is important for understanding the trend of HIV transmission routes and for developing effective donor behavioral screening policies. STUDY DESIGN AND METHODS: In 2009 to 2011, a total of 77 HIV-positive and 649 HIV-negative consented donors who screened nonreactive for hepatitis B virus, hepatitis C virus, syphilis, and alanine aminotransferase in four Retrovirus Epidemiology Donor Study-II Chinese regions received and completed a questionnaire by mail regarding their recent and past medical procedures, drug use, and sexual behaviors, etc. Exploratory and confirmatory factor analyses grouped questions into three risk factors. Multivariable logistic regression analysis examined the relationship between risk factors and HIV status adjusting for center, age, sex, and education. RESULTS: The three risk factors were test-seeking tendency, medical-related risks, and behavioral risks. In multivariable logistic regression analysis, greater testseeking tendency and behavioral risks were associated with HIV infection, with the adjusted odds ratios (ORs) being 2.2 (95% confidence interval [CI], 1.2-4.1) and 3.8 (95% CI, 1.8-7.9), respectively, but medical risks were not (OR, 1.2; 95% CI, 0.6-2.2). In comparison to less high school education, high school and more education was associated with lower risks for HIV infection, with the ORs being 0.35 (95% CI, 0.17-0.70) and 0.17 (95% CI, 0.09-0.33), respectively. CONCLUSIONS: Test-seeking tendency and high-risk sexual behaviors are important predictors of HIV infection in Chinese blood donors, suggesting that the health history inquiry used in donor selection process needs improvement to defer high-risk donors more effectively.

Original languageEnglish (US)
Pages (from-to)2431-2440
Number of pages10
JournalTransfusion
Volume53
Issue number10 PART 2
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

Fingerprint Dive into the research topics of 'An analysis of risk factors for human immunodeficiency virus infection among Chinese blood donors'. Together they form a unique fingerprint.

Cite this