An analog of myristic acid with selective toxicity for African trypanosomes

Tamara L. Doering, Jayne Raper, Laurence U. Buxbaum, Steven P. Adams, Jeffrey I. Gordon, Gerald Warren Hart, Paul T. Englund

Research output: Contribution to journalArticle

Abstract

Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, evades the host immune response through the process of antigenic variation. The variant antigen, known as the variant surface glycoprotein (VSG), is anchored to the cell surface by a glycosyl phosphatidylinositol (GPI) structure that contains myristate (n-tetradecanoate) as its only fatty acid component. The utilization of heteroatom-containing analogs of myristate was studied both in a cell-free system and in vivo. Results indicated that the specificity of fatty acid incorporation depends on chain length rather than on hydrophobicity. One analog, 10-(propoxy)decanoic acid, was highly toxic to trypanosomes in culture although it is nontoxic to mammalian cells.

Original languageEnglish (US)
Pages (from-to)1851-1854
Number of pages4
JournalScience
Volume252
Issue number5014
StatePublished - Jun 28 1991

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Trypanosomiasis
Myristic Acid
Myristates
Fatty Acids
African Trypanosomiasis
Antigenic Variation
Glycosylphosphatidylinositols
Trypanosoma brucei brucei
Cell-Free System
Poisons
Membrane Glycoproteins
Hydrophobic and Hydrophilic Interactions
Parasites
Antigens
10-propoxydecanoic acid

ASJC Scopus subject areas

  • General

Cite this

Doering, T. L., Raper, J., Buxbaum, L. U., Adams, S. P., Gordon, J. I., Hart, G. W., & Englund, P. T. (1991). An analog of myristic acid with selective toxicity for African trypanosomes. Science, 252(5014), 1851-1854.

An analog of myristic acid with selective toxicity for African trypanosomes. / Doering, Tamara L.; Raper, Jayne; Buxbaum, Laurence U.; Adams, Steven P.; Gordon, Jeffrey I.; Hart, Gerald Warren; Englund, Paul T.

In: Science, Vol. 252, No. 5014, 28.06.1991, p. 1851-1854.

Research output: Contribution to journalArticle

Doering, TL, Raper, J, Buxbaum, LU, Adams, SP, Gordon, JI, Hart, GW & Englund, PT 1991, 'An analog of myristic acid with selective toxicity for African trypanosomes', Science, vol. 252, no. 5014, pp. 1851-1854.
Doering TL, Raper J, Buxbaum LU, Adams SP, Gordon JI, Hart GW et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science. 1991 Jun 28;252(5014):1851-1854.
Doering, Tamara L. ; Raper, Jayne ; Buxbaum, Laurence U. ; Adams, Steven P. ; Gordon, Jeffrey I. ; Hart, Gerald Warren ; Englund, Paul T. / An analog of myristic acid with selective toxicity for African trypanosomes. In: Science. 1991 ; Vol. 252, No. 5014. pp. 1851-1854.
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