@article{f96dcb83dc5040ab900d5db107a1abc4,
title = "An alpha satellite DNA polymorphism specific for the centromeric region of chromosome 13",
abstract = "Alpha satellite DNA is composed of variants of a short consensus sequence that are repeated in tandem arrays in the centromeric heterochromatin of each human chromosome. To define centromeric markers for linkage studies, we screened human genomic DNA for restriction fragment length polymorphisms using a probe detecting alphoid sequences on chromosomes 13 and 21. We describe one such DNA polymorphism. Analysis of linkage of this DNA marker to other polymorphic markers in the CEPH pedigrees demonstrates linkage to markers on the proximal long arm of chromosome 13 and defines the centromeric end of the linkage map of this chromosome.",
author = "Warren, {Andrew C.} and Bowcock, {Anne M.} and Farrer, {Lindsay A.} and Antonarakis, {Stylianos E.}",
note = "Funding Information: We are grateful to Dr. M. B. Petersen, Johns Hopkins University, for preparing genomic filters; Dr. A. L. Bak, University of Aarhus, Denmark, for supplying the alphoid probe aRI(680),21-208; Dr. A. Bale, Yale University, for probe pCR1360 recognizing locus D13S36; Dr. C. Buys, University of Groningen, for probe pG2E3-1 recognizing locus D13Sll; Dr. M. Shull, University of Cincinatti, for probe ~78 l-3 recognizing locus ATPlALl. We thank J. M. Strayer for help in preparation of Fig. 1. This study was supported by NIH Grants HD24605, NS26454, and GM28428. A.C.W. was supported by a Clinician Scientist Award from the W. M. Keck Foundation and is grateful to the Alzheimer{\textquoteright}s Association for interest and support.",
year = "1990",
month = may,
doi = "10.1016/0888-7543(90)90525-Y",
language = "English (US)",
volume = "7",
pages = "110--114",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",
}