An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging

Jessica Mavadia, Jiefeng Xi, Yongping Chen, Xingde Li

Research output: Contribution to journalArticle

Abstract

We present an all-fiber-optically based endoscope platform for simultaneous optical coherence tomography (OCT) and fluorescence imaging. This design entails the use of double-clad fiber (DCF) in the endoscope for delivery of OCT source and fluorescence excitation light while collecting the backscattered OCT signal through the single-mode core and fluorescence emission through the large inner cladding of the DCF. Circumferential beam scanning was performed by rotating a 45° reflector using a miniature DC motor at the distal end of the endoscope. Additionally, a custom DCF coupler and a wavelength division multiplexer (WDM) were utilized to seamlessly integrate both imaging modalities to achieve an entirely fiber-optically based dual-modality imaging system. We demonstrated simultaneous intraluminal 3D OCT and 2D (surface) fluorescence imaging in ex vivo rabbit esophagus using the dual-modal endomicroscopy system. Structural morphologies (provided by OCT) and fluorophore distribution (provided by the fluorescence module) could be clearly visualized, suggesting the potential of the dual-modality system for future in vivo and clinical applications.

Original languageEnglish (US)
Pages (from-to)2851-2859
Number of pages9
JournalBiomedical Optics Express
Volume3
Issue number11
DOIs
StatePublished - Nov 1 2012

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Optical Imaging
Optical Coherence Tomography
Endoscopy
fiber optics
platforms
tomography
endoscopes
Endoscopes
fluorescence
fibers
Fluorescence
esophagus
rabbits
couplers
Esophagus
division
reflectors
delivery
modules
direct current

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging. / Mavadia, Jessica; Xi, Jiefeng; Chen, Yongping; Li, Xingde.

In: Biomedical Optics Express, Vol. 3, No. 11, 01.11.2012, p. 2851-2859.

Research output: Contribution to journalArticle

Mavadia, Jessica ; Xi, Jiefeng ; Chen, Yongping ; Li, Xingde. / An all-fiber-optic endoscopy platform for simultaneous OCT and fluorescence imaging. In: Biomedical Optics Express. 2012 ; Vol. 3, No. 11. pp. 2851-2859.
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