An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells

Brendan P. Cormack, Nafisa Ghori, Stanley Falkow

Research output: Contribution to journalArticlepeer-review

Abstract

Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to done a lectin from a Candida species. Deletion of this adhesin reduced adherence of C. glabrata to human epithelial cells by 95 percent. The adhesin, encoded by the EPA1 gene, is likely a glucan-cross- linked cell-wall protein and binds to host-cell carbohydrate, specifically recognizing asialo-lactosyl-containing carbohydrates.

Original languageEnglish (US)
Pages (from-to)578-582
Number of pages5
JournalScience
Volume285
Issue number5427
DOIs
StatePublished - Jul 23 1999

ASJC Scopus subject areas

  • General

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