An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

Brian M. Sicari, J. Peter Rubin, Christopher L. Dearth, Matthew T. Wolf, Fabrisia Ambrosio, Michael Boninger, Neill J. Turner, Douglas J. Weber, Tyler W. Simpson, Aaron Wyse, Elke H.P. Brown, Jenna L. Dziki, Lee E. Fisher, Spencer Brown, Stephen F. Badylak

Research output: Contribution to journalArticlepeer-review

Abstract

Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.

Original languageEnglish (US)
Article number234ra58
JournalScience translational medicine
Volume6
Issue number234
DOIs
StatePublished - Apr 30 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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