Amyotrophic Lateral Sclerosis and the Respiratory System

Andrew T. Braun, Candelaria Caballero-Eraso, Noah Lechtzin

Research output: Contribution to journalReview article

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that always affects the respiratory muscles. It is characterized by degeneration of motor neurons in the brain and spinal cord. Respiratory complications are the most common causes of death in ALS and typically occur within 3 to 5 years of diagnosis. Because ALS affects both upper and lower motor neurons, it causes hyperreflexia, spasticity, muscle fasciculations, muscle atrophy, and weakness. It ultimately progresses to functional quadriplegia. ALS most commonly begins in the limbs, but in about one-third of cases it begins in the bulbar muscles responsible for speech and swallowing.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalClinics in Chest Medicine
Volume39
Issue number2
DOIs
StatePublished - Jun 1 2018

Fingerprint

Amyotrophic Lateral Sclerosis
Respiratory System
Motor Neurons
Fasciculation
Abnormal Reflexes
Respiratory Muscles
Quadriplegia
Muscle Spasticity
Muscular Atrophy
Muscle Weakness
Deglutition
Neurodegenerative Diseases
Cause of Death
Spinal Cord
Extremities
Muscles
Brain

Keywords

  • Diaphragm
  • Noninvasive ventilation
  • Secretion clearance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Amyotrophic Lateral Sclerosis and the Respiratory System. / Braun, Andrew T.; Caballero-Eraso, Candelaria; Lechtzin, Noah.

In: Clinics in Chest Medicine, Vol. 39, No. 2, 01.06.2018, p. 391-400.

Research output: Contribution to journalReview article

Braun, Andrew T. ; Caballero-Eraso, Candelaria ; Lechtzin, Noah. / Amyotrophic Lateral Sclerosis and the Respiratory System. In: Clinics in Chest Medicine. 2018 ; Vol. 39, No. 2. pp. 391-400.
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