TY - JOUR
T1 - Amyotrophic lateral sclerosis and its mimics/variants
T2 - A comprehensive review
AU - Yedavalli, Vivek S.
AU - Patil, Abhijit
AU - Shah, Parinda
N1 - Publisher Copyright:
© 2018 Journal of Clinical Imaging Science
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018
Y1 - 2018
N2 - Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in progressive neuronal destruction and eventual loss of voluntary muscular function. These entities are often challenging to distinguish and accurately diagnose given overlapping clinical pictures and overall rarity. This group of diseases has a high morbidity and mortality rate overall and delineating each type of disease can help guide appropriate clinical management and improve quality of life for patients. Of all MNDs, amyotrophic lateral sclerosis (ALS) is by far the most common comprising 80%-90% of cases. However, other mimics and variants of ALS can appear similar both clinically and radiographically. In this review, we delve into the epidemiological, physiological, neuroimaging, and prognostic characteristics and management of ALS and its most common MND mimics/variants. In doing so, we hope to improve accuracy in diagnosis and potential management for this rare group of diseases.
AB - Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in progressive neuronal destruction and eventual loss of voluntary muscular function. These entities are often challenging to distinguish and accurately diagnose given overlapping clinical pictures and overall rarity. This group of diseases has a high morbidity and mortality rate overall and delineating each type of disease can help guide appropriate clinical management and improve quality of life for patients. Of all MNDs, amyotrophic lateral sclerosis (ALS) is by far the most common comprising 80%-90% of cases. However, other mimics and variants of ALS can appear similar both clinically and radiographically. In this review, we delve into the epidemiological, physiological, neuroimaging, and prognostic characteristics and management of ALS and its most common MND mimics/variants. In doing so, we hope to improve accuracy in diagnosis and potential management for this rare group of diseases.
KW - Amyotrophic lateral sclerosis
KW - Bulbar muscular atrophy
KW - Postpolio syndrome
KW - Primary lateral sclerosis
KW - Progressive bulbar palsy
KW - Progressive muscular atrophy
KW - Spinal
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U2 - 10.4103/jcis.JCIS_40_18
DO - 10.4103/jcis.JCIS_40_18
M3 - Review article
AN - SCOPUS:85061174559
VL - 8
JO - Journal of Clinical Imaging Science
JF - Journal of Clinical Imaging Science
SN - 2156-7514
IS - 1
M1 - 247035
ER -