Amyloidosis of the liver on shear wave elastography: case report and review of literature

Dmitry S. Trifanov, Manish Dhyani, Jacob R. Bledsoe, Joseph Misdraji, Atul K. Bhan, Raymond T. Chung, Anthony E. Samir

Research output: Contribution to journalArticlepeer-review

Abstract

Amyloidosis is extremely rare, with an estimated 2225 new US cases reported annually. Signs and symptoms of the disease are subtle and imaging findings are not pathognomonic. Currently, diagnosis requires biopsy to demonstrate the deposition of amyloid. Elastography is a new imaging modality that evaluates tissue elasticity. It has shown to have efficacy in characterizing thyroid nodules, detecting prostate cancer, and staging liver fibrosis. We present a case of hepatic amyloidosis in a 51-year-old male that demonstrates significantly increased stiffness with a median value of 99.1 kPa (range 25.7–188.9 kPa) on shear-wave elastography (SWE) imaging, which is significantly higher than the cut-off range reported for cirrhosis on SWE (10.4–11.5 kPa). This finding raises the possibility that elastographic imaging may be sensitive to tissue mechanical changes induced by amyloid deposition.

Original languageEnglish (US)
Pages (from-to)3078-3083
Number of pages6
JournalAbdominal Imaging
Volume40
Issue number8
DOIs
StatePublished - Aug 9 2015
Externally publishedYes

Keywords

  • Amyloidosis
  • Elastography
  • Liver biopsy
  • Liver fibrosis
  • SWE
  • Ultrasound elastography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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