Amyloidosis in bone

Edward F McCarthy

doi:10.1007/978-1-4471-6578-1_70

Amyloidosis in bone

Edward F McCarthy

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5-15 % of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.

Original language	English (US)
Title of host publication	Tumors and Tumor-Like Lesions of Bone: For Surgical Pathologists, Orthopedic Surgeons and Radiologists
Publisher	Springer-Verlag London Ltd
Pages	933-937
Number of pages	5
ISBN (Print)	9781447165781, 9781447165774
DOIs	https://doi.org/10.1007/978-1-4471-6578-1_70
State	Published - Jan 1 2015

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4471-6578-1_70

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abstract = "Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5-15 % of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.",

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AB - Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5-15 % of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.

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Amyloidosis in bone

Abstract

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