TY - JOUR
T1 - Amyloidogenesis in Alzheimer's disease
T2 - basic biology and animal models
AU - Sisodia, Sangram S.
AU - Price, Donald L.
PY - 1992/10
Y1 - 1992/10
N2 - A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
AB - A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
UR - http://www.scopus.com/inward/record.url?scp=0026940267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026940267&partnerID=8YFLogxK
U2 - 10.1016/0959-4388(92)90033-H
DO - 10.1016/0959-4388(92)90033-H
M3 - Article
C2 - 1422121
AN - SCOPUS:0026940267
SN - 0959-4388
VL - 2
SP - 648
EP - 652
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 5
ER -