Abstract
A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 648-652 |
| Number of pages | 5 |
| Journal | Current Opinion in Neurobiology |
| Volume | 2 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1992 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Amyloidogenesis in Alzheimer's disease : basic biology and animal models. / Sisodia, Sangram S.; Price, Donald L.
In: Current Opinion in Neurobiology, Vol. 2, No. 5, 1992, p. 648-652.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amyloidogenesis in Alzheimer's disease
T2 - basic biology and animal models
AU - Sisodia, Sangram S.
AU - Price, Donald L.
PY - 1992
Y1 - 1992
N2 - A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
AB - A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026940267&partnerID=8YFLogxK
U2 - 10.1016/0959-4388(92)90033-H
DO - 10.1016/0959-4388(92)90033-H
M3 - Article
C2 - 1422121
AN - SCOPUS:0026940267
VL - 2
SP - 648
EP - 652
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 5
ER -