Amyloidogenesis in Alzheimer's disease: basic biology and animal models

Sangram S. Sisodia, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.

Original languageEnglish (US)
Pages (from-to)648-652
Number of pages5
JournalCurrent Opinion in Neurobiology
Volume2
Issue number5
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Neuroscience(all)

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