Amyloidogenesis in Alzheimer's disease: basic biology and animal models

Sangram S. Sisodia; Donald L. Price

doi:10.1016/0959-4388(92)90033-H

Amyloidogenesis in Alzheimer's disease: basic biology and animal models

Sangram S. Sisodia, Donald L. Price

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.

Original language	English (US)
Pages (from-to)	648-652
Number of pages	5
Journal	Current Opinion in Neurobiology
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/0959-4388(92)90033-H
State	Published - Oct 1992

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0959-4388(92)90033-H

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abstract = "A principal neuropathological hallmark of Alzheimer's disease is deposition of β-amyloid, composed primarily of a 4 kD peptide, Aβ. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for Aβ formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.",

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