Amyloid precursor protein expression in circulating monocytes and brain macrophages from patients with HIV-associated cognitive impairment

Ari Vehmas, James Lieu, Carlos A. Pardo, Justin C. McArthur, Suzanne Gartner

Research output: Contribution to journalArticlepeer-review

Abstract

We examined amyloid precursor protein (APP) surface expression on circulating leukocytes and in brain tissues from normal individuals and HIV+ subjects with cognitive impairment. Most monocytes, and a subset of B-lymphocytes, expressed APP, while T-lymphocytes, granulocytes, and natural killer (NK) cells did not. CD14bright/CD16+ monocytes expressed the highest levels, and CD14dim/CD16+ cells were negative, suggesting a relationship with activation. Higher APP+ monocyte levels correlated with increased numbers of CD16+ monocytes, but not with the degree of cognitive impairment. Treatment of monocytes with M-CSF, but not LPS, upregulated APP expression. In the brain, APP appeared as axonal immunoreactivity and diffuse plaques, and APP+ perivascular macrophages were seen in cases with severe dementia. APP may facilitate monocyte entry into the brain.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalJournal of Neuroimmunology
Volume157
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Dec 2004

Keywords

  • APP
  • CD16
  • M-CSF
  • Macrophage
  • Monocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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