@article{fccc2e66d02f471aaa4b5e8fb05f9c5e,
title = "Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: The BIOCARD cohort",
abstract = "This article examines the diffeomorphometry of magnetic resonance imaging-derived structural markers for the amygdala, in subjects with symptomatic Alzheimer's disease (AD). Using linear mixed-effects models we show differences between those with symptomatic AD and controls. Based on template centered population analysis, the distribution of statistically significant change is seen in both the volume and shape of the amygdala in subjects with symptomatic AD compared with controls. We find that high-dimensional vertex based markers are statistically more significantly discriminating (p < 0.00001) than lower-dimensional markers and volumes, consistent with comparable findings in presymptomatic AD. Using a high-field 7T atlas, significant atrophy was found to be centered in the basomedial and basolateral subregions, with no evidence of centromedial involvement.",
keywords = "Alzheimer's disease, Amygdala, MCI, MRI, Shape",
author = "{BIOCARD Research Team} and Miller, {Michael I.} and Laurent Younes and Ratnanather, {J. Tilak} and Timothy Brown and Huong Trinh and Lee, {David S.} and Daniel Tward and Mahon, {Pamela B.} and Susumu Mori and Marilyn Albert",
note = "Funding Information: This study is supported in part by grants from the Johns Hopkins Brain Sciences Institute and National Institutes of Health : U01-AG03365 , P50-AG005146 , R01 EB008171 , and P41-RR015241 . The BIOCARD study consists of 7 Cores with the following members: (1) the Administrative Core (Marilyn Albert and Barbara Rodzon), (2) the Clinical Core (Ola Selnes, Marilyn Albert, Rebecca Gottesman, Ned Sacktor, Anja Soldan, Guy McKhann, Scott Turner, Leonie Farrington, Maura Grega, Daniel D'Agostino, Sydney Feagen, David Dolan, and Hillary Dolan), (3) the Imaging Core (Michael Miller, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, Thomas Reigel, Elizabeth Postell, William Schneider, and Laurent Younes), (4) the Biospecimen Core (Richard O'Brien, Abhay Moghekar, and Richard Meehan), (5) the Informatics Core (Roberta Scherer, Curt Meinert, David Shade, Ann Ervin, Jennifer Jones, Matt Toepfner, Lauren Parlett,April Patterson, and Lisa Lassiter), the (6) Biostatistics Core (Mei-Cheng Wang, Shanshan Li, and Yi Lu), and (7) the Neuropathology Core (Juan Troncoso, Barbara Crain, Olga Pletnikova, Gay Rudow, and Karen Fisher). ",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.neurobiolaging.2014.06.032",
language = "English (US)",
volume = "36",
pages = "S3--S10",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "S1",
}