Amygdala Central Nucleus Lesions Disrupt Increments, But Not Decrements, in Conditioned Stimulus Processing

Peter C. Holland, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

The effects of neurotoxic lesions of the amygdala central nucleus (CN) on changes in the associability of a conditioned stimulus (CS) in appetitive Pavlovian conditioning were examined in 2 experiments with rats. In Experiment 1, CN lesions had no effect on the reduction in the associability of a CS produced by preexposure to that cue (latent inhibition). In Experiment 2, CN lesions prevented the enhancement of the associability of a CS that is normally observed when an inconsistent predictive relation is arranged between that CS and another cue. The results support previous claims that the amygdala CN is involved in broad-based incremental, but not decremental, changes in the processing of CSs in Pavlovian conditioning.

Original languageEnglish (US)
Pages (from-to)246-253
Number of pages8
JournalBehavioral Neuroscience
Volume107
Issue number2
DOIs
StatePublished - Apr 1 1993

ASJC Scopus subject areas

  • Behavioral Neuroscience

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