Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting

Michael McDannald, Erin Kerfoot, Michela Gallagher, Peter C Holland

Research output: Contribution to journalArticle

Abstract

When exposed to pairings of a visual stimulus with food delivery, rats normally acquire both conditioned orienting responses directed toward the visual stimulus and conditioned food-related responses. Consistent with the results of previous lesion studies, reversible inactivation of amygdala central nucleus function before each conditioning session prevented the acquisition of conditioned orienting responses, whereas food-related behaviors were acquired normally. By contrast, neither inactivation nor neurotoxic lesions of central nucleus affected the expression of previously acquired conditioned orienting responses. Thus, the central nucleus is apparently not critical to the maintenance of information required for conditioned orienting, but instead is necessary for memory storage elsewhere. Specialized roles for components of a circuit for conditioned orienting, which includes the central nucleus, the substantia nigra, and dorsolateral striatum, are discussed.

Original languageEnglish (US)
Pages (from-to)240-248
Number of pages9
JournalEuropean Journal of Neuroscience
Volume20
Issue number1
DOIs
Publication statusPublished - Jul 2004

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Keywords

  • Amygdala central nucleus
  • Attention
  • Conditioning
  • NBQX
  • Orienting
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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