Amplification units containing human N-myc and c-myc genes

K. W. Kinzler, B. A. Zehnbauer, G. M. Brodeur, R. C. Seeger, J. M. Trent, P. S. Meltzer, B. Vogelstein

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


The amplification units in human tumors containing amplified myc genes were examined. The amplification unit in all cases consisted of a large genomic region coamplified with the coding region of the myc genes themselves. In eight independent neuroblastomas containing N-myc amplifications, the amplification unit was highly conserved among the different neuroblastomas, with some neuroblastomas containing almost identical units. In contrast, five tumor cell lines containing c-myc amplifications exhibited amplification units that were more variable in size (90 to 300 kilobases) and sequence content; at least three different patterns of c-myc amplification units could be discerned.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number4
StatePublished - 1986

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Amplification units containing human N-myc and c-myc genes'. Together they form a unique fingerprint.

Cite this