Amplification units containing human N-myc and c-myc genes

K. W. Kinzler, B. A. Zehnbauer, G. M. Brodeur, R. C. Seeger, Jeffrey M. Trent, P. S. Meltzer, B. Vogelstein

Research output: Contribution to journalArticle

Abstract

The amplification units in human tumors containing amplified myc genes were examined. The amplification unit in all cases consisted of a large genomic region coamplified with the coding region of the myc genes themselves. In eight independent neuroblastomas containing N-myc amplifications, the amplification unit was highly conserved among the different neuroblastomas, with some neuroblastomas containing almost identical units. In contrast, five tumor cell lines containing c-myc amplifications exhibited amplification units that were more variable in size (90 to 300 kilobases) and sequence content; at least three different patterns of c-myc amplification units could be discerned.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • General

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