AMPK in the brain: Its roles in energy balance and neuroprotection

Gabriele V. Ronnett, Santosh Ramamurthy, Amy M. Kleman, Leslie E. Landree, Susan Aja

Research output: Contribution to journalArticlepeer-review

Abstract

Adenosine monophosphate-activated protein kinase (AMPK) senses metabolic stress and integrates diverse physiological signals to restore energy balance. Multiple functions are indicated for AMPK in the CNS. While all neurons sense their own energy status, some integrate neuro-humoral signals to assess organismal energy balance. A variety of disease states may involve AMPK, so determining the underlying mechanisms is important. We review the impact of altered AMPK activity under physiological (hunger, satiety) and pathophysiological (stroke) conditions, as well as therapeutic manipulations of AMPK that may improve energy balance.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalJournal of Neurochemistry
Volume109
Issue numberSUPPL. 1
DOIs
StatePublished - May 1 2009

Keywords

  • AMP-activated protein kinase
  • C75
  • Energy balance
  • Neurons
  • Obesity
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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