AMPICILLIN TREATMENT FAILURE OF APPARENTLY β-LACTAMASE-NEGATIVE HAEMOPHILUS INFLUENZAE TYPE b MENINGITIS DUE TO NOVEL β-LACTAMASE

Lorry G. Rubin, Robert H. Yolken, Antone A. Medeiros, E. Richard Moxon

Research output: Contribution to journalArticlepeer-review

Abstract

Documented ampicillin treatment failures of systemic Haemophilus influenzae type b infections have been associated with synthesis of a TEM-1 β-lactamase. A patient with H. influenzae type b meningitis in whom ampicillin treatment failed is described; the isolate was β-lactamase-negative according to the cell suspension chromogenic cephalosporin assay. The false-negative result occurred in a strain which elaborated a novel, plasmid-mediated β-lactamase with charateristics which distinguish it from TEM-1 β-lactamase. Clinically important ampicillin resistance in H. influenzae type b occurs by mechanisms other than by synthesis of TEM-1 β-lactamase. Diagnostic microbiology laboratories should perform antibiotic susceptibility tests in addition to tests for β-lactamase production.

Original languageEnglish (US)
Pages (from-to)1008-1010
Number of pages3
JournalThe Lancet
Volume318
Issue number8254
DOIs
StatePublished - Nov 7 1981

ASJC Scopus subject areas

  • Medicine(all)

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