Ampicillin and amoxicillin

Alasdair M. Geddes; Ian M. Gould; Jason A. Roberts; M. Lindsay Grayson; Sara E. Cosgrove

doi:10.1201/9781315152110

Ampicillin and amoxicillin

Alasdair M. Geddes, Ian M. Gould, Jason A. Roberts, M. Lindsay Grayson, Sara E. Cosgrove

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Ampicillin and ampicillin-like agents, such as amoxicillin, have many similar properties, but also some important differences. They are all semisynthetic penicillins derived from the penicillin nucleus, but differ in their bioavailability and pharmacokinetic features. The two key agents in this group are ampicillin and amoxicillin, in terms of both their individual properties and the fact that they have both been combined with the beta-lactamase inhibitors, sulbactam (see Chapter 15, Ampicillin-sulbactam) and clavulanic acid (see Chapter 14, Amoxicillin-clavulanic acid), respectively, to broaden their antibacterial spectrum of activity. Ampicillin and amoxicillin will be discussed in detail in this chapter, but information regarding the other, now unused ampicillin-like compounds is summarized in Table 5.1 because they have no special advantages over ampicillin/amoxicillin.

Original language	English (US)
Title of host publication	Kucers the Use of Antibiotics
Subtitle of host publication	A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
Publisher	CRC Press
Pages	100-135
Number of pages	36
ISBN (Electronic)	9781498747967
ISBN (Print)	9781498747950
DOIs	https://doi.org/10.1201/9781315152110
State	Published - Jan 1 2017

ASJC Scopus subject areas

General Medicine
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1201/9781315152110

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abstract = "Ampicillin and ampicillin-like agents, such as amoxicillin, have many similar properties, but also some important differences. They are all semisynthetic penicillins derived from the penicillin nucleus, but differ in their bioavailability and pharmacokinetic features. The two key agents in this group are ampicillin and amoxicillin, in terms of both their individual properties and the fact that they have both been combined with the beta-lactamase inhibitors, sulbactam (see Chapter 15, Ampicillin-sulbactam) and clavulanic acid (see Chapter 14, Amoxicillin-clavulanic acid), respectively, to broaden their antibacterial spectrum of activity. Ampicillin and amoxicillin will be discussed in detail in this chapter, but information regarding the other, now unused ampicillin-like compounds is summarized in Table 5.1 because they have no special advantages over ampicillin/amoxicillin.",

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Ampicillin and amoxicillin

Abstract

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