Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

Cristina Gil-Lamaignere; Emmanuel Roilides; Avgi Maloukou; Irene Georgopoulou; George Petrikkos; Thomas J. Walsh

doi:10.1093/jac/dkf198

Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

Cristina Gil-Lamaignere, Emmanuel Roilides, Avgi Maloukou, Irene Georgopoulou, George Petrikkos, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes(PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

Original language	English (US)
Pages (from-to)	1027-1030
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	50
Issue number	6
DOIs	https://doi.org/10.1093/jac/dkf198
State	Published - Dec 1 2002
Externally published	Yes

Keywords

Amphotericin B formulations
Polymorphonuclear leucocytes
Scedosporium

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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10.1093/jac/dkf198

Cite this

Gil-Lamaignere, C., Roilides, E., Maloukou, A., Georgopoulou, I., Petrikkos, G., & Walsh, T. J. (2002). Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum. Journal of Antimicrobial Chemotherapy, 50(6), 1027-1030. https://doi.org/10.1093/jac/dkf198

Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum. / Gil-Lamaignere, Cristina; Roilides, Emmanuel; Maloukou, Avgi et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 50, No. 6, 01.12.2002, p. 1027-1030.

Research output: Contribution to journal › Article › peer-review

Gil-Lamaignere, C, Roilides, E, Maloukou, A, Georgopoulou, I, Petrikkos, G & Walsh, TJ 2002, 'Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum', Journal of Antimicrobial Chemotherapy, vol. 50, no. 6, pp. 1027-1030. https://doi.org/10.1093/jac/dkf198

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title = "Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum",

abstract = "Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes(PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.",

keywords = "Amphotericin B formulations, Polymorphonuclear leucocytes, Scedosporium",

author = "Cristina Gil-Lamaignere and Emmanuel Roilides and Avgi Maloukou and Irene Georgopoulou and George Petrikkos and Walsh, {Thomas J.}",

note = "Funding Information: C.G.-L. and I.G. are research fellows supported by the European Commission Training and Mobility of Researchers grant FMRX-CT970145. The results of this study were presented at the Thirty-eighth meeting of the Infectious Diseases Society of America, New Orleans, LA, September 2000 (abstract 112).",

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AU - Maloukou, Avgi

AU - Georgopoulou, Irene

AU - Petrikkos, George

AU - Walsh, Thomas J.

N1 - Funding Information: C.G.-L. and I.G. are research fellows supported by the European Commission Training and Mobility of Researchers grant FMRX-CT970145. The results of this study were presented at the Thirty-eighth meeting of the Infectious Diseases Society of America, New Orleans, LA, September 2000 (abstract 112).

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N2 - Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes(PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

AB - Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes(PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

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Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

Abstract

Keywords

ASJC Scopus subject areas

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