Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus

Emmanuel Roilides, Caron A. Lyman, Joanna Filioti, Onome Akpogheneta, Tin Sein, Cristina Gil Lamaignere, Ruta Petraitiene, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

Deoxycholate amphotericin B (DAMB) and amphotericin B lipid complex (ABLC) additively augmented the fungicidal activity of pulmonary alveolar macrophages against the conidia of Aspergillus fumigatus. DAMB, ABLC, and liposomal amphotericin B similarly displayed additive effects with polymorphonuclear leukocytes in damaging the hyphal elements of A. fumigatus.

Original languageEnglish (US)
Pages (from-to)1974-1976
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume46
Issue number6
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Amphotericin B formulations exert additive antifungal activity in combination with pulmonary alveolar macrophages and polymorphonuclear leukocytes against Aspergillus fumigatus'. Together they form a unique fingerprint.

Cite this