Abstract
l-Deprenyl has dose-dependent amphetamine- and methamphetamine-like discriminative stimulus properties in rats and monkeys. However, these actions occur only at doses that are well above the clinically relevant dose range for l-deprenyl and are likely to reflect its metabolic conversion to amphetamine products. In view of its weak potency for producing amphetamine-like effects and their slow onset, it may not be surprising that l-deprenyl does not appear to have amphetamine-like abuse potential and has been used therapeutically in the treatment of Parkinson syndrome for more than 20 years with no reported instances of abuse.
Original language | English (US) |
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Pages (from-to) | 768-773 |
Number of pages | 6 |
Journal | Clinical pharmacology and therapeutics |
Volume | 56 |
Issue number | 6 |
State | Published - Dec 1994 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)