Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate

G. C. Wagner, G. A. Ricaurte, C. E. Johanson, C. R. Schuster, L. S. Seiden

Research output: Contribution to journalArticle

Abstract

Long-lasting depletion of dopamine and concomitant loss of dopamine uptake sites follow repeated administration of methylamphetamine to rats. We found similar effects after similar treatment with d-amphetamine, but not after treatment with methyl-phenidate. Methylphenidate also failed to produce long-term depletion of regional catecholamine levels in rhesus monkeys. These long-lasting alterations of the dopaminergic system suggest that amphetamines or their metabolites have toxic interactions with dopaminergic neurons, which do not occur with methylphenidate.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalNeurology
Volume30
Issue number5
DOIs
StatePublished - May 1980

ASJC Scopus subject areas

  • Clinical Neurology

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