Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate

G. C. Wagner, George Ricaurte, C. E. Johanson, C. R. Schuster, L. S. Seiden

Research output: Contribution to journalArticle

Abstract

Long-lasting depletion of dopamine and concomitant loss of dopamine uptake sites follow repeated administration of methylamphetamine to rats. We found similar effects after similar treatment with d-amphetamine, but not after treatment with methyl-phenidate. Methylphenidate also failed to produce long-term depletion of regional catecholamine levels in rhesus monkeys. These long-lasting alterations of the dopaminergic system suggest that amphetamines or their metabolites have toxic interactions with dopaminergic neurons, which do not occur with methylphenidate.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalNeurology
Volume30
Issue number5
StatePublished - 1980
Externally publishedYes

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Methylphenidate
Amphetamine
Dopamine
Amphetamines
Dextroamphetamine
Methamphetamine
Poisons
Dopaminergic Neurons
Macaca mulatta
Catecholamines
Monkey
Neuron
Alteration
Interaction
Rat

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Wagner, G. C., Ricaurte, G., Johanson, C. E., Schuster, C. R., & Seiden, L. S. (1980). Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate. Neurology, 30(5), 547-550.

Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate. / Wagner, G. C.; Ricaurte, George; Johanson, C. E.; Schuster, C. R.; Seiden, L. S.

In: Neurology, Vol. 30, No. 5, 1980, p. 547-550.

Research output: Contribution to journalArticle

Wagner, GC, Ricaurte, G, Johanson, CE, Schuster, CR & Seiden, LS 1980, 'Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate', Neurology, vol. 30, no. 5, pp. 547-550.
Wagner, G. C. ; Ricaurte, George ; Johanson, C. E. ; Schuster, C. R. ; Seiden, L. S. / Amphetamine induces depletion of dopamine and loss of dopamine uptake sites in caudate. In: Neurology. 1980 ; Vol. 30, No. 5. pp. 547-550.
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