Amphetamine: Differentiation by d and 1 isomere of behavior involving brain norepinephrine or dopamine

Kenneth M. Taylor, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

d-Amphetamine is markedly more potent an inhibitor of catecholamine uptake by norepinephrine neurons in the brain than is 1-amphetamine, whereas the two isomers are equally active in inhibiting catecholamine uptake by the dopamine neurons of the corpus striatum. In behavioral studies, d-amphetamine is ten times as potent as 1-amphetamine in enhancing locomotor activity, while it is only twice as potent in eliciting a compulsive gnawing syndrome. This suggests that the locomotor stimulation induced by amphetamine involves central norepinephrine, while dopamine neurons play an important role in the induced compulsive gnawing behavior. Assessment of differential actions of d- and 1-amphetamine may be an efficient method to differentiate behaviors involving norepinephrine or dopamine in the brain.

Original languageEnglish (US)
Pages (from-to)1487-1489
Number of pages3
JournalScience
Volume168
Issue number3938
StatePublished - 1970

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Dextroamphetamine
Amphetamine
Dopamine
Norepinephrine
Dopaminergic Neurons
Catecholamines
Brain
Compulsive Behavior
Corpus Striatum
Locomotion
Neurons

ASJC Scopus subject areas

  • General

Cite this

Amphetamine : Differentiation by d and 1 isomere of behavior involving brain norepinephrine or dopamine. / Taylor, Kenneth M.; Snyder, Solomon H.

In: Science, Vol. 168, No. 3938, 1970, p. 1487-1489.

Research output: Contribution to journalArticle

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