Ampa/kainate receptors

Nicole L. Stricker, Richard L. Huganir

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The three major types of ionotropic glutamate receptors are the N-methyl-d-aspartate (NMDAR), a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPAR), and kainate (KAR) receptors. AM PARs and KARs mediate fast excitatory transmission, whereas NMDARs mediate a slower component of synaptic transmission which is important for modulation of synaptic and neuronal function. This chapter focuses on the mechanisms of AMPA and kainate glutamate receptor assembly, synaptic localization, and surface expression.

Original languageEnglish (US)
Title of host publicationReceptor and Ion-Channel Trafficking
Subtitle of host publicationCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
PublisherOxford University Press
ISBN (Electronic)9780191724763
ISBN (Print)9780192632241
DOIs
StatePublished - Mar 22 2012

Keywords

  • AMPAR
  • Ionotropic glutamate receptors
  • Kainate glutamate receptors
  • NMDAR
  • Neuronal function
  • Surface expression
  • Synaptic localization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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