AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF

George K.E. Umanah, Mehdi Ghasemi, Xiling Yin, Melissa Chang, Jin Wan Kim, Jianmin Zhang, Erica Ma, Leslie A. Scarffe, Yun Il Lee, Rong Chen, Kavya Tangella, Amy McNamara, Leire Abalde-Atristain, Mohamad A. Dar, Samuel Bennett, Marisol Cortes, Shaida A. Andrabi, Paschalis Thomas Doulias, Harry Ischiropoulos, Ted M. DawsonValina L. Dawson

Research output: Contribution to journalArticlepeer-review

Abstract

Umanah et al. show that the S-nitrosylation of Thorase and the transnitrosylation of NSF are responsible for NMDAR-activated trafficking of AMPARs underlying synaptic plasticity.

Original languageEnglish (US)
Article number108329
JournalCell Reports
Volume33
Issue number5
DOIs
StatePublished - Nov 3 2020

Keywords

  • AMPAR
  • ATAD1
  • GluA2
  • N-ethylmaleimide-sensitive factor
  • N-methyl-D-aspartate receptor
  • NMDAR
  • NSF
  • PICK1
  • S-nitrosylation
  • endocytosis
  • exocytosis
  • protein-interacting C kinase 1
  • thorase
  • α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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