AMPA receptor subunits define properties of state-dependent synaptic plasticity

Michelle R. Emond, Johanna M. Montgomery, Matthew L. Huggins, Jesse E. Hanson, Lifang Mao, Richard L. Huganir, Daniel V. Madison

Research output: Contribution to journalArticle

Abstract

Many synapses undergo immediate and persistent activity-dependent changes in strength via processes that fall under the umbrella of synaptic plasticity. It is known that this type of synaptic plasticity exhibits an underlying state dependence; that is, as synapses change in strength they move into distinct 'states' that are defined by the mechanism and ability to undergo future plasticity. In this study, we have investigated the molecular mechanisms that underlie state-dependent synaptic plasticity. Using intracellular application of peptides that mimic the C-terminal tail sequences of GluR1 and GluR2 AMPA receptor subtypes, combined with paired recordings of minimal synaptic connections, we have shown that AMPA receptor subtypes present in the membrane at a given time confer some properties of plasticity states. These data show that during synaptic plasticity, AMPA receptor subtypes are differentially stabilized by postsynaptic density proteins in or out of the postsynaptic membrane, and this differential synaptic expression of different AMPA receptor subtypes defines distinct synaptic states.

Original languageEnglish (US)
Pages (from-to)1929-1946
Number of pages18
JournalJournal of Physiology
Volume588
Issue number11
DOIs
StatePublished - Jun 1 2010

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ASJC Scopus subject areas

  • Physiology

Cite this

Emond, M. R., Montgomery, J. M., Huggins, M. L., Hanson, J. E., Mao, L., Huganir, R. L., & Madison, D. V. (2010). AMPA receptor subunits define properties of state-dependent synaptic plasticity. Journal of Physiology, 588(11), 1929-1946. https://doi.org/10.1113/jphysiol.2010.187229